Thursday, 15 September 2011

The future of cognitive neuroscience

I have previously written about how I think that cognitive neuroscience as a scientific discipline (and I know that this is not a universally held view) has largely moved on from publishing studies demonstrating the neural correlates of “x”, where x might be behaviours as diverse as maternal love, urinating, or thinking about god.  There are still a few of these sorts of studies published each year, and because the public are, it seems, fascinated by stories about blobs on brains, the media portrayal of cognitive neuroscience tends to focus on such findings.

Some blobs on a brain
This is all very entertaining if you like your science presented to you in a breakfast TV sofa sort of way.  However, the downside is that people who are not regular readers of the fMRI research literature think that the media portrayal of cognitive neuroscience is an accurate representation of the field.  In fact, I would argue, this is far from the case.  In my experience of working in cognitive neuroscience for the last decade or more, most researchers I have encountered are not interested in so-called “blobology”.  Instead, they work very hard each day carefully designing theoretically motivated experiments using cognitive neuroscience techniques to produce empirical data that can be used to differentiate between cognitive theories about how functions like memory, language, vision, attention, and so on, might operate.

However, the field of cognitive neuroscience is still relatively young.  As such, its accepted methodological and analytic conventions are still being worked out.  There are some statistical methods that have been used quite widely in the field, but which people are starting to identify as not being sufficiently rigorous for the kinds of interpretations that have been made.  The widespread use of these practices has happened mainly because new researchers have tended to learn fMRI methods informally through knowledge handed down by other researchers in the lab, who themselves will have learned from previous researchers, and so on, as there has been no standard textbook with a validated and generally accepted set of approved methods.  Recent articles highlighting issues such as that it is usually inappropriate to use the same dataset for selection and selective analysis, and that interaction analyses are often conducted incorrectly, have served the very useful purpose of alerting neuroscience researchers to ways in which they might improve the rigour of their analytical methods.

As far as I’m concerned, these articles have been a thoroughly excellent contribution to the field, and a sign of a healthy, thriving scientific discipline that is willing to examine its core methods for possible weaknesses and, if they are found, to highlight them prominently.  While it might seem odd that a field would allow a paper that does little more than count statistical errors in other papers to be published in the field’s flagship journal, I think it is splendid.  Other fields should care as much about their time-honoured, adamantine practices.

It is a shame that some commentators see these articles as a sign that cognitive neuroscience is weak or inherently flawed or, as one prominent figure has described it, “the soft end of science... really just at the stamp-collecting stage. There aren't any real hypotheses, more just post hoc rationalisations.”  These commentators have a tendency to dismiss the field of cognitive neuroscience with the disdain they usually lavish on areas like homeopathy, chiropractics and other such mumbo jumbo.  I feel such views are narrow-minded, and reflect the personal prejudices of people who, if they really value science and wish to encourage those who seek to practice it with the most rigour they can, might like to reconsider their preconceptions.

I just today came across an article that, to me, is a prime example of the way in which cognitive neuroscience is constantly seeking to improve as an empirical discipline.  Russ Poldrack, widely regarded as one the most sensible methodologists in the field, has a paper in press in the journal NeuroImage entitled “The Future of fMRI in Cognitive Neuroscience”.  In the article, he outlines how over the next 20 years, the field needs to increase its methodological rigour, consistently use more robust methods for statistical inference, concentrate to a greater degree on identifying connectivity patterns across the brain rather than focusing on single regions, and make other improvements to the way in which theoretical inferences are drawn from neuroimaging data.  This is an important paper, and all cognitive neuroscientists should read it.  But I believe all commentators who are sceptical about cognitive neuroscience should also read it.  It may change their view.

As Poldrack concludes:
fMRI has advanced cognitive neuroscience research in a way that has been nothing short of revolutionary, though at the same time there are fundamental limits to the standard imaging approach that have not been widely appreciated. I am hopeful that 20 years from now, the history of fMRI in cognitive neuroscience will show that the field attacked this problem head on and developed new, robust methods for better understanding the relation between mental processes and brain function.
I very much agree, and think that there is a good chance that Poldrack’s hope will be fulfilled.

ResearchBlogging.org
Poldrack RA (2011). The future of fMRI in cognitive neuroscience. NeuroImage PMID: 21856431



(edited on 15/9/11 to include ResearchBlogging citation - thanks @deevybee!)

10 comments:

  1. I hate agreeing with people that I tend to disagree with, but Ken Wilber makes a great point -

    Understanding the brain in relation to cognition and the spontaneous rise of consciousness from brain function and chemistry requires a dual approach of both empirical, physiological sciences and also psychological and spiritual depth research.

    Science, as the "new religion" of our age, has yet to integrate the universal "spiritual experience" that is, in itself, the conscious experience.

    At humanities core, I think that we all understand from the most educated to the primitive that life (or consciousness), the differentiating factor between animate and inanimate objects, stems from beyond the interaction of inanimate chemicals working together to form a cognitive system.

    All life, all consciousness, comes from a source beyond scientific understanding. It has always been, and always will be.

    But trying to derive life from atoms is just purely theoretical, and, in my opinion, foolish.

    Going down beyond even atoms, what makes subatomic particles behave as inanimate and animate? How does this continue to work?

    The force of life is as of yet understood, and the only way to get there is to integrate our comprehensive methodologies together into a more "holistic" science.

    I am excited by recent psychedelic research, as this seems to be a closer approach to a more holistic approach to scientific methodology in many fields - including neuroscience, psychology, and even pharmacology.

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  2. Thanks for your interesting comment. I agree that understanding conscious experience is an extraordinarily difficult scientific problem. I'm afraid I don't know too much about psychedelic research, but perhaps another reader might be able to comment further?

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  3. Just wanted to say excellent post and I very much agree with your points. I think people just have an profound ignorance of science when it involves people (neuroscience, psychology, etc.) which isn't entirely their fault. We need better education of these sciences to help people appreciate how great an effect these disciplines have - and have had on their lives.

    So much of medical technology has come from findings in these fields, yet people don't realise this.

    Regardless, keep at it with the blog!

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  4. Many thanks for your kind words, Jamal. I agree with you completely that educating the public (and indeed, the media) about science is key. It's up to scientists to ensure we concentrate on that, rather than the sometimes petty bickering that just turns people off.

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  5. just couldn’t leave your website before telling you that we really enjoyed the quality information you offer to your visitors… Will be back often to check up on new posts.

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  6. That's very kind of you. Thanks so much!

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  7. Excellent quality blog posts. A real contribution to neuroscience..

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  8. Wow, this blog has really interested me! Its been fascinating to see the people behind the papers talking about cognitve neuroscience in this more informal setting, having only read their formally published work. A lot of big names pop up and add their thoughts on your posts!

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  9. "All life, all consciousness, comes from a source beyond scientific understanding. It has always been, and always will be. "

    And how exactly do you know that?

    "A person is smart. People are dumb, panicky dangerous animals and you know it. Fifteen hundred years ago everybody knew the Earth was the center of the universe. Five hundred years ago, everybody knew the Earth was flat, and fifteen minutes ago, you knew that humans were alone on this planet. Imagine what you'll know tomorrow. "

    Yeah, quoting MIB is cheasy, but your point of view is exactly what has been holding science back through the onset of time.
    My question is this: How do you know we can't understand life fully from a scientific point of view?

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